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Centene

Does Centene cover Ozempic for Heart Disease Risk Reduction?

Yes. Centene covers Ozempic for heart disease risk reduction with prior authorization. Other policy requirements and your plan's benefits also apply.

Policy document

  • ACA Marketplace: Covered with requirements. See the qualification pathways below.

Earliest policy review June 2, 2026. How we verify · Check your exact plan

Full requirements: Ozempic for Heart Disease Risk Reduction (1 plan type)

Applies to ACA Marketplace plans.

Covered with requirements

Qualification pathways

You can qualify through any one of these.

CV risk reduction in T2DM — established ASCVD or high ASCVD risk

All of:

  • Diagnosis of type 2 diabetes mellitus
  • Age ≥ 18 years
  • Ozempic injection is FDA-approved for CV risk reduction in T2DM with established CVD; Ozempic tablets are approved for patients at high risk for major adverse CV events
  • Failure of ≥ 3 consecutive months of SGLT2 inhibitor or SGLT2-containing product unless clinically significant adverse effects or all contraindicated
  • Not prescribed concurrently with another GLP-1 receptor agonist or DPP-4 inhibitor
  • Dose does not exceed FDA-approved maximum
  • Failure of both preferred GLP-1s: liraglutide (Victoza) for ≥ 3 consecutive months, then Trulicity for ≥ 3 consecutive months (unless excepted)

Plus any one of:

  • Established atherosclerotic cardiovascular disease (ASCVD)
  • Indicators of high ASCVD risk (age ≥ 55 with coronary/carotid/lower-extremity artery stenosis >50%, LVH, retinopathy, other end organ damage)
  • Heart failure with preserved ejection fraction
  • Chronic kidney disease

Documentation to bring

  • Office chart notes or other clinical documentation of type 2 diabetes mellitus diagnosis
  • Documentation of established ASCVD, high ASCVD risk indicators, HFpEF, or CKD
  • Documentation of failure or contraindication/adverse effects for SGLT2 inhibitor trial ≥ 3 months
  • Documentation of failure of liraglutide (Victoza) ≥ 3 months (unless excepted)
  • Documentation of failure of Trulicity ≥ 3 months (unless excepted)
  • Confirmation of no concurrent GLP-1 receptor agonist or DPP-4 inhibitor use

Approval and renewal

  • Initial approval: 12 months
  • Renewal: every 12 months
  • Renewal: Member is responding positively to therapy. No concurrent use with another GLP-1 or DPP-4 inhibitor.

Not covered when

  • Concurrent use with another GLP-1 receptor agonist
  • Concurrent use with a DPP-4 inhibitor
  • Dose exceeding FDA-approved maximum recommended dose
  • Type 1 diabetes

Policy note: CV risk reduction for Ozempic is covered under the same T2DM criteria framework, specifically pathway I.A.3.d. Both Ozempic injection (established CVD) and Ozempic tablets (high CV risk) have FDA-approved CV indications. Coverage requires underlying T2DM diagnosis — this is not a standalone CV indication without diabetes. The policy does not separate CV risk reduction from diabetes management; both are handled under the T2DM approval pathway.

Policy effective February 26, 2026 · verified June 2, 2026 · source: Cp.Pmn.183 · View policy document (PDF)

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Questions people ask
Does Centene cover Ozempic?
Yes. Centene covers Ozempic for heart disease risk reduction with prior authorization. Other policy requirements and your plan's benefits also apply.
How long does a Ozempic approval last with Centene?
Heart Disease Risk Reduction — Applies to ACA Marketplace plans. Initial approval: 12 months. Renewal: every 12 months.
What does Centene require to renew Ozempic?
Heart Disease Risk Reduction — Applies to ACA Marketplace plans. Member is responding positively to therapy. No concurrent use with another GLP-1 or DPP-4 inhibitor.
How current is this information?
The oldest review date among the policies on this page is June 2, 2026. Each policy's effective and verification dates appear with its requirements. Confirm current benefits with your plan.

Also under Centene: Mounjaro, Wegovy, Zepbound

Ozempic under other plans: Aetna, Cigna, Humana, UnitedHealthcare, Alabama Medicaid, Arkansas Medicaid, BCBS Alabama, BCBS Arizona

All insurance plans · All medications

Summary of Centene's written policy, not a guarantee of coverage. Plans vary by employer and benefit design.