Applies to Medicaid plans.
Covered with requirementsQualification pathways
You can qualify through any one of these.
MACE risk reduction - non-diabetic patients (Ozempic as step-therapy prerequisite for Wegovy injection)
All of:
- Member is between ages ≥55 and <75
- Member does not have diabetes, as evidenced by A1C within normal range without diabetes medication
- Member has initial BMI ≥27 kg/m2 and <35 kg/m2
- Member is concurrently taking lipid-lowering and antiplatelet therapy
- Dose escalation to 2mg of Ozempic (semaglutide) must be tolerated before Wegovy injection will be authorized (2.4mg is the only strength indicated for reduction of MACE)
Plus any one of:
- Prior myocardial infarction (MI)
- Prior stroke AND peripheral arterial disease (PAD), as evidenced by intermittent claudication with ankle-brachial index <0.85, peripheral arterial revascularization procedure, or amputation due to atherosclerotic disease
Documentation to bring
- A1C lab result within normal range (confirming no diabetes) without diabetes medication
- Documentation of baseline BMI ≥27 kg/m2 and <35 kg/m2
- Documentation of qualifying CV event (prior MI; OR prior stroke AND PAD with ABI <0.85, revascularization, or amputation)
- Documentation of concurrent lipid-lowering therapy use
- Documentation of concurrent antiplatelet therapy use
- Tobacco cessation counseling documentation (if current tobacco user, within past year)
- Documentation of dose escalation to Ozempic 2mg tolerated (required before Wegovy injection authorized)
Approval and renewal
- Initial approval: 12 months
- Renewal: every 12 months
- Renewal: At least 5% reduction in BMI.
- Renewal: For Wegovy injection: must have tolerated dose escalation to 2mg of Ozempic before Wegovy authorized. Failure defined as: unable to achieve weight loss ≥5% from baseline, OR unable to achieve reduction of BMI ≥5% from baseline, OR experienced a cardiovascular event following a 5% weight loss or 5% reduction of BMI since starting medication.
Not covered when
- Patients WITH diabetes are not eligible for this MACE indication (diabetes exclusion); they should use the diabetes criteria
- BMI ≥35 kg/m2 is excluded from this MACE indication
- Ozempic 2mg is required as step therapy before Wegovy injection for MACE
Policy note: Under the 'Reduction of Major Adverse Cardiovascular Events (MACE)' section, Ozempic is listed as a NON-PREFERRED injectable agent (Wegovy injection and Ozempic are both listed; Wegovy injection is also non-preferred; Wegovy tablets are non-preferred). For diabetic patients qualifying for MACE reduction, the document directs to the diabetes category criteria. The MACE section specifically addresses non-diabetic patients. Ozempic 2mg must be tolerated as a prerequisite step before Wegovy injection for MACE is authorized. The BMI range is ≥27 and <35 kg/m2.
Policy effective April 1, 2026 · verified June 3, 2026 · source: Pdl 2026.4 · View policy document (PDF)