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Missouri Medicaid · Heart Disease Risk Reduction

Missouri Medicaid coverage for Wegovy (Heart Disease Risk Reduction)

Medicaid

Covered with requirements

What you need to qualify

  • Age 45 and older
  • BMI of 27 or higher
  • A1C no higher than 6.4%
  • Established cardiovascular disease (MI, stroke, and symptomatic_PAD)
  • On guideline-directed medical therapy (cardiovascular disease pharmaceutical therapy (unspecified))
  • Lab results confirming eligibility
  • Not being used to treat type 1 diabetes

Qualification pathways

You can qualify through any one of these.

CV Risk Reduction (MACE) — Wegovy only

All of:

  • Wegovy (non-preferred) — medical necessity for non-preferred use documented
  • Participant is aged >= 45 years
  • Documented baseline BMI >= 27 kg/m2
  • Lack of diabetes mellitus diagnosis in the past 2 years
  • Recent A1C < 6.5 within the past 3 months confirming absence of diabetes diagnosis
  • Lack of any history of anti-diabetic pharmaceutical therapy in the past 2 years
  • Documentation of current pharmaceutical therapy for cardiovascular disease

Plus any one of:

  • Documented diagnosis of myocardial infarction
  • Documented diagnosis of stroke
  • Symptomatic peripheral arterial disease — intermittent claudication with ABI < 0.85 (at rest), peripheral arterial revascularization procedure, or amputation due to ASCVD

Documentation to bring

  • Documentation of medical necessity for using Wegovy instead of preferred agent (Zepbound)
  • Participant age documentation (>= 45 years)
  • Documented baseline BMI >= 27 kg/m2
  • Documentation confirming no diabetes mellitus diagnosis in the past 2 years
  • Recent A1C < 6.5 within the past 3 months
  • Documentation confirming no anti-diabetic pharmaceutical therapy in the past 2 years
  • Documented diagnosis of qualifying CV event: myocardial infarction, stroke, or symptomatic PAD (with supporting evidence: ABI < 0.85, revascularization procedure, or amputation due to ASCVD)
  • Documentation of current pharmaceutical therapy for cardiovascular disease

Quantity limits

  • 0.25 mg/0.5 mL pen, 0.5 mg/0.5 mL pen, 1 mg/0.5 mL pen — 2 mL per 28 days
  • 1.7 mg/0.75 mL pen, 2.4 mg/0.75 mL pen — 3 mL per 28 days

Approval and renewal

  • To renew, the plan looks for staying on a maintenance dose of at least 1.7 mg.

Not covered when

  • Concurrent therapy with another GLP-1 receptor agonist
  • Unable to complete titration/dose escalation to at least 1.7 mg/dose within 6 months of beginning therapy
  • Diabetes mellitus diagnosis within past 2 years
  • Any history of anti-diabetic pharmaceutical therapy in past 2 years
  • A1C >= 6.5 on recent lab

Policy note: This is a Wegovy-specific pathway. Strictly requires absence of diabetes: no diabetes diagnosis in the past 2 years, no anti-diabetic pharmaceutical therapy in the past 2 years, and recent A1C < 6.5 (within 3 months). CVD pharma therapy is required but not specified beyond 'pharmaceutical therapy for cardiovascular disease.' Titration rules same as Wegovy weight_loss: initial approval 4 weeks, per-dose approvals during titration, must reach maintenance dose of at least 1.7 mg/dose within 6 months.

Policy effective January 29, 2026 · verified June 3, 2026 · source: policy-311.html

All Wegovy policies under Missouri Medicaid · Check your card