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Aetna · Heart Disease Risk Reduction

Aetna coverage for Ozempic (Heart Disease Risk Reduction)

Employer / Commercial Insurance

Covered with requirements

What you need to qualify

  • Age 18 and older
  • A1C of 6.5% or higher
  • Trial of metformin for at least 90 days, or a documented reason it can't be used (["intolerance", "contraindication", "inadequate_response", "MASLD", "MASH", "established_CVD", "CKD"])
  • Established cardiovascular disease (established_cardiovascular_disease)
  • Lab results confirming eligibility

Qualification pathways

You can qualify through any one of these.

Initial approval — CV risk reduction for T2DM with established CVD

All of:

  • Patient has NOT been receiving a stable maintenance dose of a GLP-1 or GIP/GLP-1 agonist for at least 3 months
  • Documentation of T2DM diagnosis via one of: A1C >= 6.5%, 2-hour PG >= 200 mg/dL on OGTT, random PG >= 200 mg/dL with hyperglycemic symptoms, or fasting PG >= 126 mg/dL (fasted >= 8 hours)
  • Established cardiovascular disease

Plus any one of:

  • Inadequate treatment response, intolerance, or contraindication to metformin
  • Requires combination therapy AND A1C >= 7.5%
  • Diagnosis of MASLD or MASH
  • Established cardiovascular disease (satisfies both the CV indication requirement and the metformin exception)

Continuation — CV risk reduction with demonstrated benefit or qualifying comorbidity

All of:

  • Patient HAS been receiving a stable maintenance dose of a GLP-1 or GIP/GLP-1 agonist for at least 3 months
  • Documentation of T2DM diagnosis confirmed
  • Established cardiovascular disease

Plus any one of:

  • Demonstrated reduction in A1C since starting therapy
  • Diagnosis of MASLD or MASH
  • Established cardiovascular disease

Documentation to bring

  • Documentation of T2DM diagnosis (A1C >= 6.5%, OR 2-hour PG >= 200 mg/dL on OGTT, OR random PG >= 200 mg/dL with hyperglycemia symptoms, OR fasting PG >= 126 mg/dL with documented >= 8-hour fast)
  • Documentation of established cardiovascular disease
  • Documentation that patient has NOT been on stable GLP-1 or GIP/GLP-1 agonist for at least 3 months (initial only)
  • Documentation of metformin inadequate response, intolerance, or contraindication; OR A1C >= 7.5% requiring combination therapy; OR qualifying comorbidity

Quantity limits

  • 2mg/3mL — 1 prefilled pen (3 mL) / 21 days; 3 prefilled pens (9 mL) / 63 days (84-day)
  • 4mg/3mL — 1 prefilled pen (3 mL) / 21 days; 3 prefilled pens (9 mL) / 63 days (84-day)
  • 8mg/3mL — 1 prefilled pen (3 mL) / 21 days; 3 prefilled pens (9 mL) / 63 days (84-day)

Approval and renewal

  • Initial approval: 12 months
  • Renewal: every 12 months
  • To renew, the plan looks for improvement in A1C and Patient must demonstrate A1C reduction since starting therapy, OR have a diagnosis of MASLD/MASH, OR have established CVD. The requirement that the patient NOT be on a stable GLP-1 dose flips to MUST be on stable dose for at least 3 months at continuation.

Policy note: CV risk reduction for Ozempic injection is covered as part of the T2DM criteria — the established CVD diagnosis serves as the qualifying exception to metformin step therapy. This policy does not separate CV risk reduction as an independent standalone indication; it is handled within the T2DM authorization framework. The patient must still have T2DM and meet the diagnosis confirmation criteria.

Policy effective March 18, 2026 · verified June 2, 2026 · source: policy-259.html

ACA Marketplace

Covered with requirements

What you need to qualify

  • Age 18 and older
  • A1C of 6.5% or higher
  • Trial of metformin for at least 90 days, or a documented reason it can't be used (["intolerance", "contraindication", "inadequate_response", "MASLD", "MASH", "established_CVD", "CKD"])
  • Established cardiovascular disease (established_cardiovascular_disease)
  • Lab results confirming eligibility

Qualification pathways

You can qualify through any one of these.

Initial approval — CV risk reduction for T2DM with established CVD

All of:

  • Patient has NOT been receiving a stable maintenance dose of a GLP-1 or GIP/GLP-1 agonist for at least 3 months
  • Documentation of T2DM diagnosis via one of: A1C >= 6.5%, 2-hour PG >= 200 mg/dL on OGTT, random PG >= 200 mg/dL with hyperglycemic symptoms, or fasting PG >= 126 mg/dL (fasted >= 8 hours)
  • Established cardiovascular disease

Plus any one of:

  • Inadequate treatment response, intolerance, or contraindication to metformin
  • Requires combination therapy AND A1C >= 7.5%
  • Diagnosis of MASLD or MASH
  • Established cardiovascular disease (satisfies both the CV indication requirement and the metformin exception)

Continuation — CV risk reduction with demonstrated benefit or qualifying comorbidity

All of:

  • Patient HAS been receiving a stable maintenance dose of a GLP-1 or GIP/GLP-1 agonist for at least 3 months
  • Documentation of T2DM diagnosis confirmed
  • Established cardiovascular disease

Plus any one of:

  • Demonstrated reduction in A1C since starting therapy
  • Diagnosis of MASLD or MASH
  • Established cardiovascular disease

Documentation to bring

  • Documentation of T2DM diagnosis (A1C >= 6.5%, OR 2-hour PG >= 200 mg/dL on OGTT, OR random PG >= 200 mg/dL with hyperglycemia symptoms, OR fasting PG >= 126 mg/dL with documented >= 8-hour fast)
  • Documentation of established cardiovascular disease
  • Documentation that patient has NOT been on stable GLP-1 or GIP/GLP-1 agonist for at least 3 months (initial only)
  • Documentation of metformin inadequate response, intolerance, or contraindication; OR A1C >= 7.5% requiring combination therapy; OR qualifying comorbidity

Quantity limits

  • 2mg/3mL — 1 prefilled pen (3 mL) / 21 days; 3 prefilled pens (9 mL) / 63 days (84-day)
  • 4mg/3mL — 1 prefilled pen (3 mL) / 21 days; 3 prefilled pens (9 mL) / 63 days (84-day)
  • 8mg/3mL — 1 prefilled pen (3 mL) / 21 days; 3 prefilled pens (9 mL) / 63 days (84-day)

Approval and renewal

  • Initial approval: 12 months
  • Renewal: every 12 months
  • To renew, the plan looks for improvement in A1C and Patient must demonstrate A1C reduction since starting therapy, OR have a diagnosis of MASLD/MASH, OR have established CVD. The requirement that the patient NOT be on a stable GLP-1 dose flips to MUST be on stable dose for at least 3 months at continuation.

Policy note: CV risk reduction for Ozempic injection is covered as part of the T2DM criteria — the established CVD diagnosis serves as the qualifying exception to metformin step therapy. This policy does not separate CV risk reduction as an independent standalone indication; it is handled within the T2DM authorization framework. The patient must still have T2DM and meet the diagnosis confirmation criteria.

Policy effective March 18, 2026 · verified June 2, 2026 · source: policy-259.html

All Ozempic policies under Aetna · Check your card